DelveInsight’s, “Thyroid Cancer Pipeline Insight, 2022,” report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Thyroid Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
In the Thyroid Cancer Pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Thyroid Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Key takeaways from the Thyroid Cancer Pipeline Report
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Thyroid Cancer Overview
Thyroid cancer starts in the cells that make up your thyroid gland. The thyroid gland makes hormones that help control many processes in your body. Thyroid cancer is relatively common enough so that all of us will know somebody with thyroid cancer. There are more than 50,000 new cases of thyroid cancer each year in the United States. Women are more likely to develop thyroid cancer at a ratio of three to one. Thyroid cancer can occur in any age group, although it is most common after age 30 and its aggressiveness increases significantly in patients above 55 years of age. Thus, most people with thyroid cancer are women over age 30. The majority of patients present with a nodule on their thyroid which typically does not cause symptoms. Remember, likely over 90% of thyroid nodules are not cancer. But, when a thyroid cancer does begin to grow within a thyroid gland, it almost always does so within a discrete nodule within the thyroid. Said differently, the entire thyroid isn’t a cancer; the cancer grows from within a nodule which is within the thyroid. It’s normal to have few or no symptoms early on. One of the most common symptoms is a lump (growth) called a nodule in the neck. This might be found during a routine physical. Most thyroid nodules are not cancer. A biopsy is the only way to know for sure that you have thyroid cancer. Small pieces of tissue are taken from the thyroid and tested for cancer. The treatment choices depends on the type of thyroid cancer person have, test results, the stage of the cancer, and the overall health. Most thyroid cancers are slow to grow and spread (metastasize). But some kinds can grow and spread quickly.
Recent Developmental Activities in the Thyroid Cancer Pipeline Report
Thyroid Cancer Emerging Drugs
Donafenib: Suzhou Zelgen Biopharmaceuticals
Donafenib, an orally administered multikinase inhibitor, is being developed by Suzhou Zelgen Biopharmaceuticals for the treatment of Late stage cancers. The product targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Currently, it is in phase 3 of development stage for the treatment of thyroid cancer.
Anlotinib: Jiangsu Chia-Tai Tianqing Pharmaceutical
Anlotinib is an orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit. Currently, it is in phase 3 of development stage for the treatment of thyroid cancer.
Nivolumab: Bristol-Myers Squibb
Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response. Currently, it is in phase 2 of development stage for the treatment of thyroid cancer.
RX208: Suzhou NeuPharma
RX108 is a novel small-molecule inhibitor of sodium-potassium adenosine triphosphatase (Na+/K+-ATPase). Na+/K+-ATPase is an ion carrier protein and controls transportation of Na+ and K+ across the cell membrane. Studies have shown that Na+/K+-ATPase serves as a scaffold for the assembly of multiple-protein signaling complex and plays an important role in the regulation of cell growth, motility, and proliferation beyond that of ion transport. Expression of Na+/K+-ATPase is elevated in various tumors. Inhibition of Na+/K+-ATPase in cancer cells triggers a series of downstream signaling activities that lead to cell-cycle arrest, apoptosis and autophagic cell death. Targeting Na+/K+-ATPase offers a potential new approach for the development of novel anti-cancer therapies.
AIC100: AffyImmune Therapeutics
AffyImmune’s lead product, AIC100, is an affinity-tuned, ICAM-1 targeted, third generation CAR T cell therapy. AIC100’s CAR has an affinity to ICAM-1 similar to the affinity between naturally-occurring T cells and their targets, which is much lower than most CARs used to date and reduces on-target off-tumor toxicities. AIC100 also expresses SSTR2 for real-time monitoring of CAR T cell distribution and activity.Preclinical studies demonstrate that AIC100 induces robust and enduring tumor eradication without toxicity-related relapse or fatality in various solid tumor models. Studies also suggest the potential for combination with anti-PD-1 therapies. AffyImmune is currently enrolling patients in our Phase I trial for ARTC.
Learn more about the emerging Thyroid Cancer pipeline therapies @ Thyroid Cancer Clinical Trials
Thyroid Cancer Pipeline Therapeutic Analysis
There are approx. 40+ key companies which are developing the therapies for Thyroid Cancer. The companies which have their Thyroid Cancer drug candidates in the most advanced stage, i.e. phase III include, Suzhou Zelgen Biopharmaceuticals.
Scope of the Thyroid Cancer Pipeline Report
Dive deep into rich insights into new Thyroid Cancer Emerging Therapies, visit @ Thyroid Cancer Drugs
Table of content
Key Questions
Current Treatment Scenario and Emerging Therapies:
For further information on the Thyroid Cancer pipeline therapeutics, reach out Thyroid Cancer Pipeline Outlook Report
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