Kolkata News Today

Global Small-cell Lung Cancer Pipeline Insight | Clinical Trials Evaluation Research Report 2022 by DelveInsight

 Breaking News
  • No posts were found

Global Small-cell Lung Cancer Pipeline Insight | Clinical Trials Evaluation Research Report 2022 by DelveInsight

April 27
11:40 2022
Global Small-cell Lung Cancer Pipeline Insight | Clinical Trials Evaluation Research Report 2022 by DelveInsight
Small-cell Lung Cancer Pipeline
Small-cell Lung Cancer Pipeline constitutes 100+ key companies continuously working towards developing 100+ Small-cell Lung Cancer treatment therapies, analyzes DelveInsight

DelveInsight’s Small-cell Lung Cancer Pipeline Insight 2022 report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the Small-cell Lung Cancer pipeline domain. 

 

Some of the essential takeaways from the Small-cell Lung Cancer Pipeline report:

  • DelveInsight’s Small-cell Lung Cancer Pipeline analysis depicts a robust space with 100+ active players working to develop 100+ Small-cell Lung Cancer treatment pipeline therapies. 
  • Some of the key Small-cell Lung Cancer companies proactively working to develop potential drug candidates to improve the Small-cell Lung Cancer treatment scenario include Ascentage Pharma, Merck & Co, AstraZeneca, Advenchen Laboratories, Advanced Accelerator Applications, Trillium Therapeutics, Wigen Biomedicine, Linton Pharm, Carrick Therapeutics, Xencor, Aileron Therapeutics, Ipsen, Celgene, Lee’s Pharmaceutical Limited, AbbVie, Chipscreen Biosciences, Shanghai Henlius Biotech, CSPC ZhongQi Pharmaceutical Technology, Impact Therapeutics, Amgen, Bristol-Myers Squibb, Genentech, Sorrento Therapeutics, DAIICHI SANKYO COMPANY, BioNTech, Harpoon Therapeutics, Genprex, Inc., Tarveda Therapeutics, Taizhou HoudeAoke Biomedical Co., Ltd., BeiGene, HaiHe Biopharma, Kartos Therapeutics, Inc., Boehringer Ingelheim, Y-mAbs Therapeutics, CStone Pharmaceuticals, EpicentRx, Inc., Pfizer, Mologen,  Cybrexa Therapeutics, and many others.
  • Essential Small-cell Lung Cancer pipeline therapies such as APG-1252, SYHA 1807, BNT 411, BMS 986012, LY 2510924, Serplulimab, Tiragolumab, Socazolimab, DS-7300, ABBV-011, HPN328, REQORSA, PEN-221, Gimatecan, LP002, LY01610, PLM60,  Ociperlimab, KRT-232, BI 764532, Nivatrotamab, CS1001, RRx-001, PF-06821497CC-90011, AL3810, Lefitolimod, ALRN-6924,   CBX-12, and others are under development in different phases of clinical trials.
  • In March 2022, Luye Pharma Group announced that it has filed a New Drug Application (NDA) in Hong Kong, China for Lurbinectedin, for the treatment of adult patients with metastatic Small-cell Lung Cancer (SCLC) with disease progression on or after receiving platinum-based chemotherapy. Lurbinectedin is an innovative oncology drug licensed to Luye Pharma by PharmaMar.
  • In March 2022, Harpoon Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation for HPN328, a delta-like ligand 3- (DLL3) targeting TriTAC®, for the treatment of Small-cell Lung Cancer (SCLC). A Phase 1/2 clinical trial is currently ongoing for HPN328 in the SCLC patient population. 
  • In March 2022, Akeso, Inc. announced that it has entered into a collaboration agreement with Shenzhen Chipscreen Biosciences, Ltd. (SHA Code 688321) to conduct a Phase Ib/II clinical study of combination therapy of Cadonilimab (PD-1/CTLA-4 bispecific antibody, AK104) and Chiauranib (a highly selective Aurora B/VEGFR/PDGFR /c-Kit/CSF1R inhibitor) in patients with ES-SCLC which progressed on combination therapy of platinum-based chemotherapy and PD-(L)1 inhibitor as first-line treatment.
  • In March 2022, Shanghai Henlius Biotech, Inc., announced that the investigational new drug application (IND) of an international multicenter phase 3 studies of HANSIZHUANG (serplulimab), an innovative anti-PD-1 monoclonal antibody (mAb) independently developed by the Company, in combination with chemotherapy and concurrent radiotherapy in patients with limited-stage Small-Cell Lung Cancer (LS-SCLC) has been approved by the National Medical Products Administration (NMPA). Previously, the global multi-center phase 3 study of HANSIZHUANG for the first-line treatment of extensive-stage small-cell lung cancer (ES-SCLC) has met the primary study endpoint of the overall survival (OS), and its NDA in China and MAA in the EU are expected to be filed in 2022, making HANSIZHUANG potentially the world’s first PD-1 inhibitor for the first-line treatment of SCLC.
  • In January 2022, Genprex, Inc. announced that it has expanded its oncology research and development pipeline to include Small-cell Lung Cancer (SCLC) as an additional disease indication for its lead drug candidate, REQORSA™ Immunogene Therapy.  
  • In December 2021, Shanghai Henlius Biotech, Inc. announced that the first interim analysis met the primary study endpoint of the overall survival (OS) of Phase 3 clinical study (NCT04063163) of its innovative PD-1 inhibitor serplulimab in combination with chemotherapy in previously untreated patients with extensive-stage small-cell lung cancer (ES-SCLC). There is no anti-PD-1 mAb approved for the treatment of extensive-stage small-cell lung cancer (ES-SCLC) worldwide.

 

Request a sample and discover more about the report offerings @ Small-cell Lung Cancer Emerging Therapies

 

The Small-cell Lung Cancer pipeline report lays down detailed profiles of the pipeline assets, a comparative analysis of clinical and non-clinical stage Small-cell Lung Cancer products, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, as well as the opportunities and risks in the Small-cell Lung Cancer pipeline landscape.

 

Small-cell Lung Cancer Overview

Small-cell Lung Cancer is characterized as a neuroendocrine carcinoma because the cancer cells have features of nerve cells and endocrine (hormone-secreting) cells. Endocrine tissue is a specialized tissue that contains hormone-secreting cells. These hormones have a variety of functions within the body. Common Small-cell Lung Cancer symptoms include a cough that doesn’t get better, chest pain that is worse when coughing, laughing or taking a deep breath, shortness of breath, coughing up blood (hemoptysis), and hoarseness or wheezing. Some affected individuals can develop loss of appetite, unintended weight loss, fatigue, and recurrent episodes of lung infections such as pneumonia or bronchitis. A Small-cell Lung Cancer diagnosis is based upon the identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests.

 

Find out more about the disease and recent developments @ Small-cell Lung Cancer Pipeline Assessment

 

Small-cell Lung Cancer Pipeline Drugs

Drug

Company

Phase

MoA

RoA

AMG 757

Amgen 

Phase II

Cytotoxic T lymphocyte stimulants

Intravenous

APG-1252

Ascentage Pharma

Phase I/II

Bcl-X protein inhibitors

Intravenous

SYHA 1807

CSPC Zhong Qi Pharmaceutical Technology

Phase I

Lysine specific demethylase 1 inhibitors

Oral

BNT 411

BioNTech

Phase I/II

Toll-like receptor 7 agonists

Intravenous

BMS 986012

Bristol-Myers Squibb

Phase II

Fucosyl GM1 ganglioside inhibitors

Intravenous

KRT-232

Kartos Therapeutics, Inc.

Phase II

Proto-oncogene protein c mdm2 inhibitors

Oral

Serplulimab

Henlix Biotech

Phase III

Programmed cell death-1 receptor antagonists

Intravenous

Tiragolumab

Genentech

Phase III

TIGIT protein inhibitors

Intravenous

Socazolimab

Sorrento Therapeutics

Phase III

Programmed cell death-1 ligand-1 inhibitors

Intravenous

 

Small-cell Lung Cancer Therapeutics Assessment

The Small-cell Lung Cancer Pipeline report proffers an integral view of the Small-cell Lung Cancer emerging novel therapies segmented by Stage, Product Type,  Molecule Type,  Mechanism of Action and Route of Administration.

 

Scope of the Small-cell Lung Cancer Pipeline Report

  • Coverage: Global 
  • Therapeutic Assessment By Small-cell Lung Cancer Product Type: Mono, Combination, Mono/Combination
  • Therapeutic Assessment By Small-cell Lung Cancer Clinical Trial Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III, Pre-registration, Inactive candidates
  • Therapeutics Assessment By Small-cell Lung Cancer Therapeutics Route of Administration: Oral, Intravenous, Inhalation, Subcutaneous
  • Therapeutics Assessment By Small-cell Lung Cancer Therapies Molecule Type: Gene therapy, Stem cell therapy, Small molecules
  • Therapeutics Assessment By Small-cell Lung Cancer Therapies Mechanism of Action:  CXCR4 receptor antagonists, Antibody-dependent cell cytotoxicity, Fucosyl GM1 ganglioside inhibitors, Toll-like receptor 7 agonists, Proto-oncogene protein c-bcl-2 inhibitors, Lysine specific demethylase 1 inhibitors
  • Key Small-cell Lung Cancer Companies: Ascentage Pharma, Merck & Co, AstraZeneca, Advenchen Laboratories, Advanced Accelerator Applications, Trillium Therapeutics, Wigen Biomedicine, Linton Pharm, Carrick Therapeutics, Xencor, Aileron Therapeutics, Ipsen, Celgene, Lee’s Pharmaceutical Limited, AbbVie, Chipscreen Biosciences, Shanghai Henlius Biotech, CSPC ZhongQi Pharmaceutical Technology, Impact Therapeutics, Amgen, Bristol-Myers Squibb, Genentech, Sorrento Therapeutics, DAIICHI SANKYO COMPANY, BioNTech, Harpoon Therapeutics, Genprex, Inc., Tarveda Therapeutics, Taizhou HoudeAoke Biomedical Co., Ltd., BeiGene, HaiHe Biopharma, Kartos Therapeutics, Inc., Boehringer Ingelheim, Y-mAbs Therapeutics, CStone Pharmaceuticals, EpicentRx, Inc., Pfizer, and many others.
  • Key Small-cell Lung Cancer Pipeline Therapies:  APG-1252, SYHA 1807, BNT 411, BMS 986012, LY 2510924, Serplulimab, Tiragolumab, Socazolimab, DS-7300, ABBV-011, HPN328, REQORSA, PEN-221, Gimatecan, LP002, LY01610, PLM60,  Ociperlimab, KRT-232, BI 764532, Nivatrotamab, CS1001, RRx-001, PF-06821497, CC-90011, AL3810, and others

 

Dive deep into rich insights for emerging therapies and assessment, visit @ Small-cell Lung Cancer Emerging Therapies

 

Table of Contents 

1

Introduction

2

Executive Summary

3

Small-cell Lung Cancer: Overview

4

Pipeline Therapeutics

5

Late Stage Products (Phase III)

5.1 

Serplulimab : Henlix Biotech

5.2 

Tiragolumab : Genentech

6

Mid Stage Products (Phase II)

6.1

KRT-232 : Kartos Therapeutics

7

Early Stage Products (Phase I/II)

7.1

BNT 411: BioNTech

8

Early Stage Products (Phase I)

8.1

SYHA 1807: CSPC ZhongQi Pharmaceutical Technology

9

Therapeutic Assessment

10

Inactive Products

11

Collaborations Assessment- Licensing / Partnering / Funding

12

Small-cell Lung Cancer- Unmet Needs

13

Small-cell Lung Cancer- Market Drivers and Barriers

14

Appendix

15

About DelveInsight

 

About DelveInsight

DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.  Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Ankit Nigam
Email: Send Email
Phone: +19193216187
Address:304 S. Jones Blvd #2432
City: Albany
State: New York
Country: United States
Website: https://www.delveinsight.com/report-store/small-cell-lung-cancer-pipeline-insight